Implementation of herbal medication is traditionally employed for treating broad spectrum diseases. Among this remedial flora, Nigella sativa is emerging as potent pharmaceutically significant plant with supportive religious background. Produce formulated from N. sativa have been found effective as anti-inflammatory, analgesic, antipyretic, antimicrobial, antineoplastic drugs for various disorders and also as an ideal healer for variety of wounds. As in daily routine, minor injuries, abrases and burns are common and inevitable. In consequence, wound healing which is a physiological and systematic process in response to injury may be impaired due to several external and internal factors like in case of several infections and in diabetic patients, and it may lead to diabetic foot ulcers with significant morbidity and mortality risks. Retarted diabetic wounds’ healing is mainly due to interlukin-8; hyperglycemia and other contributing factors are like poor epithelialization, angiogenesis and skin regeneration. Biochemically, black seeds contain 35% fatty acids, 21% proteins and 38% carbohydrates and vast variety of other vitamins and minerals. Among them, thymoquinone frequently reported constituent as potent wound healer either of diabetic origin or due to other reasons. So far explored broad spectrum efficacy of this plant is also directly a proof of hadith of Prophet Muhammad ((HPBU: ―Use black seeds regularly; because, it cures every disease excluding death‖. So its biochemical screening and dose optimization to cure and heal not only the diabetic wounds in better way but also for other pharamcognosal pursuits should be explored in future to provide general public of third world countries like Pakistan, as local cost effective alternative drug in replacement of expensive synthetic drugs for better medical treatment
